Package: crispRdesignR
Type: Package
Title: Guide Sequence Design for CRISPR/Cas9
Version: 1.1.7
Encoding: UTF-8
Authors@R: c(
    person("Dylan", "Beeber", email = "dylan.beeber@gmail.com", role = c("aut", "cre")),
    person("Frederic", "Chain", role = "aut"))
Description: Designs guide sequences for CRISPR/Cas9 genome editing and
        provides information on sequence features pertinent to guide
        efficiency. Sequence features include annotated off-target
        predictions in a user-selected genome and a predicted
        efficiency score based on the model described in Doench et al.
        (2016) <doi:10.1038/nbt.3437>. Users are able to import
        additional genomes and genome annotation files to use when
        searching and annotating off-target hits. All guide sequences
        and off-target data can be generated through the 'R' console
        with sgRNA_Design() or through 'crispRdesignR's' user interface
        with crispRdesignRUI(). CRISPR (Clustered Regularly Interspaced
        Short Palindromic Repeats) and the associated protein Cas9
        refer to a technique used in genome editing.
URL: <https://github.com/dylanbeeber/crispRdesignR>
License: GPL-3
Depends: R (>= 2.10)
Imports: Biostrings, gbm, GenomicRanges, BiocGenerics, IRanges,
        GenomeInfoDb, S4Vectors, rtracklayer, stringr, vtreat, shiny,
        DT
Suggests: BSgenome.Scerevisiae.UCSC.sacCer3
RoxygenNote: 7.1.0
Config/pak/sysreqs: cmake make libbz2-dev libicu-dev liblzma-dev
        libuv1-dev libxml2-dev libssl-dev xz-utils zlib1g-dev
Repository: https://dylanbeeber.r-universe.dev
Date/Publication: 2023-04-13 13:25:43 UTC
RemoteUrl: https://github.com/dylanbeeber/crisprdesignr
RemoteRef: HEAD
RemoteSha: 00487e4987d2ce7e660bced05edace610f55b7f4
NeedsCompilation: no
Packaged: 2026-09-19 07:03:41 UTC; root
Author: Dylan Beeber [aut, cre],
  Frederic Chain [aut]
Maintainer: Dylan Beeber <dylan.beeber@gmail.com>